Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reverse T3 levels in affective disorders.

B F Kjellman, J G Ljunggren, J Beck-Friis

    Psychiatry Research
    |September 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ionic influence on human erythrocyte catechol-O-methyltransferase activity.

    Biochemical pharmacology·2010
    Same author

    Melatonin in rat pineal gland and serum; rapid parallel decline after light exposure at night.

    Neuroscience letters·2009
    Same author

    Geomagnetic activity influences the melatonin secretion at latitude 70 degrees N.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2002
    Same author

    Melatonin production in patients with duodenal ulcer.

    Neuro endocrinology letters·2001
    Same author

    Melatonin and epileptic seizures in patients with acute intermittent porphyria.

    Epileptic disorders : international epilepsy journal with videotape·2001
    Same author

    [Ulcer protective effect of melatonin during artificial simulation of desynchronization in rats].

    Vestnik Rossiiskoi akademii meditsinskikh nauk·2000

    Serum levels of reverse triiodothyronine (T3) did not differ in major depressive disorder patients compared to controls. However, increased reverse T3 and decreased T3 were linked to more severe depressive symptoms.

    Area of Science:

    • Endocrinology
    • Neuroscience
    • Psychiatry

    Background:

    • Thyroid hormones play a crucial role in mood regulation.
    • Alterations in thyroid hormone levels have been observed in patients with major depressive disorder.
    • Reverse triiodothyronine (rT3) is a metabolically inactive iodothyronine with potential implications in depression.

    Purpose of the Study:

    • To investigate serum levels of reverse triiodothyronine (rT3) in patients with acute major depressive disorder.
    • To compare rT3 levels between depressed patients, euthymic patients with affective disorders, and healthy controls.
    • To explore the relationship between rT3 levels and the severity of depressive symptoms.

    Main Methods:

    • Serum levels of rT3, triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were measured.

    Related Experiment Videos

  • Clinical symptoms were assessed using the Comprehensive Psychopathological Rating Scale (CPRS).
  • Patients were categorized based on Dexamethasone Suppression Test (DST) response, melancholia, and depression type (primary/secondary).

    • Main Results:

    • No significant differences in rT3 levels were found between acute major depressive disorder patients, euthymic affective disorder patients, and healthy controls.
    • No significant differences in rT3 levels were observed based on DST response, melancholia, or depression type.
    • In patients with acute major depressive disorder, significantly higher rT3 and lower T3 levels were associated with more pronounced depressive symptoms (CPRS scores).

    Conclusions:

    • Serum rT3 levels do not appear to be a distinguishing biomarker for major depressive disorder in general.
    • A subset of patients with acute major depressive disorder may exhibit altered thyroid hormone profiles, specifically increased rT3 and decreased T3, correlating with symptom severity.
    • These findings suggest a potential role for thyroid hormone dysregulation in the pathophysiology of severe depressive episodes.