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Drug absorption VIII: Kinetics of GI absorption of methotrexate

V S Chungi, D W Bourne, L W Dittert

Journal of Pharmaceutical Sciences

|April 1, 1978

Abstract:

The absorption of methotrexate from the lumen of the rat small intestine, in situ, was found to obey Michaelis--Menten kinetics. The values of Vmax and Km for the absorption process were 4.78 X 10(-7) M/min and 1.49 X 10(-5) M, respectively.

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