Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mechanical ventilation with superimposed high frequency oscillation in the normal rat.

A Harf, R Le Gall, H K Chang

    Respiration Physiology
    |October 1, 1983
    PubMed
    Summary

    High frequency oscillations added to conventional mechanical ventilation improved oxygen exchange in rats by enhancing ventilation distribution. This technique shows promise for improving gas exchange efficacy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Laparoscopic total extra-peritoneal (TEP) inguinal hernia repair under local anesthesia by topical lidocaine injection.

    Hernia : the journal of hernias and abdominal wall surgery·2022
    Same author

    ["Somatic symptom disorders" in adolescence. A systematic review of the recent literature].

    L'Encephale·2021
    Same author

    Taxonomic and functional diversity of the microbiome in a jet fuel contaminated site as revealed by combined application of in situ microcosms with metagenomic analysis.

    The Science of the total environment·2019
    Same author

    Bone mineral density among Korean females aged 20-50 years: influence of age at menarche (The Korea National Health and Nutrition Examination Survey 2008-2011).

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2017
    Same author

    Hybrid Surgical Technique: Single-Site Laparoscopic Myomectomy Using Robotic-Assisted Laparoscopic Suture.

    Journal of minimally invasive gynecology·2016
    Same author

    Ten-Year Experience With Bowel Transplantation at Seoul St. Mary's Hospital.

    Transplantation proceedings·2016

    Area of Science:

    • Respiratory Physiology
    • Mechanical Ventilation
    • Pulmonary Gas Exchange

    Background:

    • Conventional mechanical ventilation (CMV) can lead to alveolar hypoventilation.
    • High-frequency oscillations (HFO) are explored to improve ventilation-perfusion matching.

    Purpose of the Study:

    • To evaluate the gas exchange efficacy of CMV with superimposed HFO (CMV-HFO).
    • To assess the impact of oscillation amplitude and dead space on gas exchange.

    Main Methods:

    • 24 normal rats were mechanically ventilated and instrumented in a body box.
    • CMV-HFO was applied with varying oscillation amplitudes (0.75, 1.25 ml/kg) and dead space volumes.
    • Blood gases were analyzed during CMV-HFO and CMV alone.

    Main Results:

    Related Experiment Videos

    • No significant changes in arterial PCO2 were observed, except in one group where oscillations alone improved gas exchange.
    • A decrease in alveolar-arterial oxygen difference was noted in 20/24 animals with CMV-HFO.
    • Improved VA/Q homogeneity was suggested by the reduction in oxygen difference.

    Conclusions:

    • CMV-HFO can improve oxygenation by enhancing ventilation distribution.
    • The technique shows potential for optimizing gas exchange during mechanical ventilation.