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Interferon induction in Toxoplasma gondii infected mice
Zentralblatt Fur Bakteriologie, Mikrobiologie Und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten Und Parasitologie = International Journal of Microbiology and Hygiene. A, Medical Microbiology, Infectious
|September 1, 1983
Summary
Interferon (IFN-R) activity appears in mouse serum within 24 hours of Toxoplasma gondii infection or TLA injection. Survivors receiving TLA showed faster gamma interferon (IFN-r) response within 6 hours.
Area of Science:
- Immunology
- Parasitology
- Molecular Biology
Background:
- Toxoplasma gondii is a common parasite that can cause toxoplasmosis.
- Interferons (IFNs) are crucial cytokines in the innate immune response against viral and parasitic infections.
- Understanding the kinetics of IFN production during T. gondii infection is important for developing therapeutic strategies.
Purpose of the Study:
- To investigate the temporal dynamics of interferon activity in mice following infection or antigen challenge with Toxoplasma gondii.
- To compare the interferon response between acute and chronic infection models.
Main Methods:
- Mice were inoculated intraperitoneally with live T. gondii or Toxoplasma lysate antigen (TLA).
- Serum samples were collected at various time points post-inoculation.
- Interferon-R (IFN-R) and gamma interferon (IFN-r) activities were measured in serum samples.
Main Results:
- Regular IFN-R activity was detected in serum within 24 hours of T. gondii or TLA inoculation.
- Mice surviving subchronic infection (14-28 days) and subsequently injected with TLA exhibited a rapid IFN-r response within 6 hours.
Conclusions:
- Toxoplasma gondii infection and TLA challenge rapidly induce interferon activity in mice.
- A heightened and accelerated gamma interferon response is observed in previously infected or TLA-sensitized mice.