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Single breath cardiac output--enhanced sampling and analysis techniques.

N S Deno, E Kamon, J S Ultman

    Aviation, Space, and Environmental Medicine
    |November 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    This study improved the single breath method for measuring cardiac output (Q) using advanced computer techniques. The enhanced method provides accurate and repeatable measurements of cardiac output during exercise.

    Area of Science:

    • Cardiovascular Physiology
    • Respiratory Physiology
    • Biomedical Engineering

    Background:

    • The single breath method is a non-invasive technique for estimating cardiac output (Q).
    • Previous limitations in computer sampling and analysis hindered its accuracy and reliability.
    • Accurate measurement of cardiac output is crucial for assessing cardiovascular function, especially during exercise.

    Purpose of the Study:

    • To enhance the single breath method for measuring cardiac output (Q) using novel computer sampling and analysis.
    • To evaluate the variability, accuracy, and repeatability of the improved method.
    • To increase the success rate of the breathing maneuver for reliable data acquisition.

    Main Methods:

    • Carbon dioxide (CO2) elimination rate measured breath-by-breath via expired flow rate and CO2 concentration integration.

    Related Experiment Videos

  • Arterial CO2 concentration determined from end-tidal CO2 partial pressure.
  • Mixed venous CO2 concentration measured using a modified single breath technique.
  • Evaluation conducted on four healthy men during rest and three exercise workloads (0.5-2 L/min VO2).

    • Main Results:

    • Coefficients of variation for cardiac output measurements at rest, 1.0 L/min VO2, and 2.0 L/min VO2 were 18.2%, 10.5%, and 8.8%, respectively.
    • Regression analyses showed similarity between the enhanced single breath method and the direct Fick method for cardiac output and oxygen consumption.
    • The probability of a successful breathing maneuver, defined by r2 > 0.9, approached 100%.

    Conclusions:

    • The enhanced single breath method offers improved accuracy and repeatability for cardiac output measurement.
    • New computer techniques significantly increase the success rate of the breathing maneuver.
    • This refined method provides a reliable tool for assessing cardiac output during physiological studies, particularly exercise.