Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Familial chronic lymphocytic leukemia.

C Y Neuland, W A Blattner, D L Mann

    Journal of the National Cancer Institute
    |December 1, 1983
    PubMed
    Summary

    This study investigated familial chronic lymphocytic leukemia (CLL), revealing varied disease progression and unique immunogenetic markers. Findings suggest a genetic predisposition and potential subclinical persistence of lympho-proliferative processes in CLL patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    How do referees visually explore? An in-situ examination of the referential head and eye movements of football referees.

    Journal of sports sciences·2024
    Same author

    "What needs to be seen": An exploration into the visual anticipation behaviour of different skill-level football referees while observing long passes on-field.

    Human movement science·2022
    Same author

    Hemovigilance and the Notify Library.

    Immunohematology·2021
    Same author

    A brief overview of clinical significance of blood group antibodies.

    Immunohematology·2018
    Same author

    Hemovigilance and the Notify Library.

    Immunohematology·2018
    Same author

    CYP3A4 genotype is associated with sildenafil concentrations in patients with heart failure with preserved ejection fraction.

    The pharmacogenomics journal·2017

    Area of Science:

    • Hematology
    • Genetics
    • Oncology

    Background:

    • Familial chronic lymphocytic leukemia (CLL) cases present unique challenges in understanding disease pathogenesis and progression.
    • Previous documentation identified CLL in a father and four of his five offspring, necessitating further investigation into familial patterns.

    Observation:

    • Disease progression varied among affected siblings, including spontaneous remission in one patient and development of lung adenocarcinoma in an unaffected sibling.
    • Cell surface analysis revealed distinct immunoglobulin profiles among CLL patients, with shared mu- and delta-type heavy chains and kappa-type light chains in two siblings.
    • One patient with spontaneous remission showed a perturbed percentage of cells with specific surface markers, indicating potential subclinical lympho-proliferative activity.

    Findings:

    Related Experiment Videos

    • Immunogenetic markers were associated with CLL occurrence but were not linked to HLA.
    • Abnormalities of chromosome 12, including trisomy 12 and complex rearrangements, were observed in B-cells of two patients, but not in their T-cells.

    Implications:

    • These findings highlight the complex genetic underpinnings of familial CLL and suggest potential roles for specific immunogenetic markers and chromosomal abnormalities.
    • The observation of subclinical persistence and varied clinical patterns underscores the need for personalized monitoring and treatment strategies in familial CLL.