Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional tolerance to lorazepam in the rat.

R G Lister, S E File, D J Greenblatt

    Psychopharmacology
    |January 1, 1983
    PubMed
    Summary

    Rats developed functional tolerance to lorazepam

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Response to diazepam in sons of alcoholics.

    Alcoholism, clinical and experimental research·1992
    Same author

    Benzodiazepine receptor binding of nonbenzodiazepines in vivo: alpidem, zolpidem and zopiclone.

    Brain research bulletin·1992
    Same author

    Mental illness, pharmacotherapy, and automobile operation: what is the risk?

    Journal of clinical psychopharmacology·1992
    Same author

    Bioavailability studies of drugs with nonlinear pharmacokinetics: I. Tracer dose AUC varies directly with serum concentration.

    Journal of clinical pharmacology·1992
    Same author

    Pharmacokinetics and preliminary observations of behavioral changes following administration of midazolam to dogs.

    Journal of veterinary pharmacology and therapeutics·1992
    Same author

    Fluoxetine impairs clearance of alprazolam but not of clonazepam.

    Clinical pharmacology and therapeutics·1992

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Behavioral Science

    Background:

    • Tolerance to sedative-hypnotic drugs is a significant clinical concern.
    • Understanding the mechanisms of lorazepam tolerance is crucial for optimizing its therapeutic use.

    Purpose of the Study:

    • To investigate the nature of tolerance to the sedative effects of lorazepam in rats.
    • To differentiate between functional and dispositional tolerance to lorazepam.

    Main Methods:

    • Rats were treated with varying doses of lorazepam daily or every other day.
    • Behavioral effects were assessed using a hole-board apparatus.
    • Plasma and brain concentrations of lorazepam were measured.

    Main Results:

    • Repeated daily or intermittent lorazepam administration induced tolerance to its sedative effects.
    • Tolerance was found to be functional, not dispositional, as drug concentrations did not explain the reduced effect.
    • Sodium pentobarbitone treatment did not induce tolerance to lorazepam's effects.

    Conclusions:

    • Functional tolerance develops to the sedative action of lorazepam.
    • The development of tolerance is dependent on the drug itself, not solely on sedative exposure.
    • These findings have implications for understanding benzodiazepine tolerance and withdrawal.

    Related Experiment Videos