Measurements of nuclear sizes of committed hematopoietic progenitor cells compared to leukemic blasts from human bone marrow smears

By measurements of the nuclear sizes of normal and of leukemic myeloblasts and monoblasts in colored smears, the differences estimated in surviving cells with phase contrast were confirmed. The median nuclear size of normal myeloblasts is the smallest one and differs significantly from that of the normal monoblasts and AML myeloblasts. The median nuclear size of normal monoblasts significantly exceeds values of normal myeloblasts and of AMoL monoblasts. Both leukemic blasts cover a wide range of nuclear diameters, but do not differ from one another, while normal myeloblasts have a smaller dispersion than normal monoblasts. The difference of leukemic blasts and normal progenitor cells is to be emphasized.