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Brain parenchyma penetration by intrathecal nonionic iopamidol
AJNR. American Journal of Neuroradiology
|November 1, 1983
Summary
Intrathecal iopamidol shows patchy brain penetration in dogs, similar to other contrast agents. This diffusion rate does not explain differences in neurotoxicity.
Area of Science:
- Neuroradiology
- Neuroscience
- Pharmacology
Background:
- Nonionic, water-soluble contrast media like iopamidol are used in myelography.
- Understanding parenchymal penetration is crucial for assessing clinical complications.
Purpose of the Study:
- To compare the degree and depth of brain penetration of intrathecal iopamidol in greyhound dogs.
- To evaluate iopamidol's penetration in relation to other contrast agents and potential neurotoxicity.
Main Methods:
- Adult greyhound dogs received intrathecal iopamidol (280 mg I/ml).
- Coronal computed tomographic scanning of the brain was performed at 15 and 60 minutes post-injection.
- Penetration was compared with historical data of metrizamide and methylglucamine iothalamate.
Main Results:
- Patchy iopamidol penetration was observed in cortical sulci at 15 minutes.
- Increased distribution and concentration were noted by 60 minutes.
- No significant difference in penetration depth or degree was found compared to metrizamide and methylglucamine iothalamate at 60 minutes.
Conclusions:
- Iopamidol exhibits a similar diffusion rate across the cerebrospinal fluid/brain interface as other contrast media.
- Differences in neurotoxicity are unlikely to be due to variations in contrast medium diffusion across this interface.