Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperosmolarity and cardiac function in chronic diabetic rat heart.

D R Bielefeld, C S Pace, B R Boshell

    The American Journal of Physiology
    |December 1, 1983
    PubMed
    Summary

    Hyperosmolar solutions, common in diabetes, surprisingly improve heart function in diabetic rats by enhancing calcium availability, unlike in normal hearts. This suggests a potential protective mechanism in diabetic cardiovascular health.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Food addiction and personality traits: A three-levels meta-analysis of correlational studies.

    Eating behaviors·2025
    Same author

    Do Attachment, Educator Characteristics and Youth-Educator Relationship Matter in 6-Month Changes of Institutionalized Adolescents?

    Clinical psychology & psychotherapy·2024
    Same author

    Continuity and discontinuity of attachment patterns: a short-term longitudinal pilot study using a sample of late-adopted children and their adoptive mothers.

    Attachment & human development·2011
    Same author

    'Adoption and attachment theory' the attachment models of adoptive mothers and the revision of attachment patterns of their late-adopted children.

    Child: care, health and development·2010
    Same author

    Norepinephrine-mediated calcium signaling is altered in vascular smooth muscle of diabetic rat.

    Cell calcium·1997
    Same author

    Diabetes, insulin, and Alabama.

    Alabama medicine : journal of the Medical Association of the State of Alabama·1995

    Area of Science:

    • Cardiovascular Physiology
    • Diabetic Pathophysiology
    • Metabolic Regulation

    Background:

    • Serum hyperosmolarity is a hallmark of poorly controlled diabetes mellitus.
    • Diabetic hearts exhibit altered responses to physiological challenges.

    Purpose of the Study:

    • To investigate the effects of hyperosmolar solutions on cardiac function in normal and diabetic rat hearts.
    • To determine the role of extracellular calcium concentration in mediating these effects.

    Main Methods:

    • Isolated rat hearts from normal and diabetic models were perfused with varying osmolarity solutions (glucose, mannitol).
    • Cardiac output and coronary conductance were measured under different extracellular calcium concentrations.
    • Functional responses were compared between diabetic and normal hearts.

    Related Experiment Videos

    Main Results:

    • Increased perfusate osmolarity reduced aortic output in both normal and diabetic hearts, but less severely in diabetic hearts.
    • Diabetic hearts showed enhanced aortic output and prolonged performance under hyperosmolar conditions, especially at low extracellular calcium (1 mM).
    • Coronary conductance improved in diabetic hearts with hyperosmolar perfusate, while it declined in normal hearts.

    Conclusions:

    • Hyperosmolar solutions exert a positive inotropic effect on diabetic rat hearts, particularly at physiological calcium levels.
    • These findings suggest hyperosmolarity may enhance calcium availability in diabetic hearts, contributing to improved cardiac performance.
    • The results indicate a potential adaptive mechanism in diabetic hearts responding to hyperosmolar stress.