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Related Experiment Video

Updated: May 11, 2026

Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry
08:07

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Published on: May 19, 2020

A nonpolymorphic class I gene in the murine major histocompatibility complex.

A L Mellor, E H Weiss, M Kress

    Cell
    |January 1, 1984
    PubMed
    Summary

    DNA sequence analysis reveals nonpolymorphic class I genes at the Q10 locus. These genes may encode liver-specific polypeptides, contrasting with polymorphic H-2K genes.

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    Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
    09:32

    Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

    Published on: October 15, 2021

    Area of Science:

    • Immunogenetics
    • Molecular Biology
    • Genomics

    Background:

    • Class I genes play crucial roles in immune responses and cell surface interactions.
    • The Qa2,3 locus in mice harbors class I genes with largely unknown functions.
    • Previous research suggested the Q10 gene's potential involvement in genetic information transfer at the H-2K locus.

    Purpose of the Study:

    • To analyze the DNA sequence of the Q10 class I gene from C57BL/10 mice.
    • To compare the Q10 sequence with a cDNA clone from SWR/J mice.
    • To investigate the structural and functional implications of sequence variations in class I genes.

    Main Methods:

    • DNA sequencing of the Q10 gene.
    • Comparison with a liver cDNA clone (pH16).
    • Analysis of exon structures and potential protein products.

    Main Results:

    • The Q10 gene sequence is nearly identical to the pH16 cDNA clone from a different mouse haplotype.
    • Exon 5 exhibits an unusual structure, suggesting the polypeptide may not be membrane-anchored.
    • Class I genes at the Q10 locus appear nonpolymorphic, unlike H-2K genes.

    Conclusions:

    • The Q10 and pH16 sequences likely represent allelic nonpolymorphic class I genes.
    • These genes may encode uncharacterized liver-specific polypeptides.
    • The lack of polymorphism suggests Q10 locus genes are either not recipients of genetic exchange or are under strong selective pressure.