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Ventilatory drive in normal man during semistarvation.

H Baier, P Somani

    Chest
    |February 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Reduced caloric intake severely depresses hypoxic ventilatory drive, even with adequate protein. Achieving a minimum daily caloric intake is crucial for preserving respiratory control during semistarvation.

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    Area of Science:

    • Physiology
    • Nutrition Science
    • Respiratory Medicine

    Background:

    • Reduced caloric intake can impact physiological functions.
    • Ventilatory drive is crucial for maintaining respiration.
    • The role of caloric intake versus nitrogen balance in respiratory control is not fully understood.

    Purpose of the Study:

    • To investigate the effects of reduced caloric intake on ventilatory drive in normal volunteers.
    • To determine if maintaining nitrogen balance is sufficient to preserve ventilatory drive during semistarvation.
    • To differentiate the effects of caloric intake on hypoxic versus hypercapnic ventilatory drive.

    Main Methods:

    • A ten-day semistarvation study was conducted on two groups of six healthy volunteers.
    • Group 1 received parenteral amino acids (550 kcal/d); Group 2 received amino acids plus safflower oil (1,100 kcal/d).

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  • Hypoxic ventilatory drive was assessed using an index (parameter A) relating minute ventilation (VE) to hypoxia; hypercapnic drive was assessed by the slope of VE vs. arterial PCO2 (delta VE/delta PaCO2).

    • Main Results:

    • Hypoxic ventilatory drive (parameter A) significantly decreased in Group 1 (550 kcal/d) but remained stable in Group 2 (1,100 kcal/d).
    • Hypercapnic ventilatory drive (delta VE/delta PaCO2) remained unchanged in both groups.
    • These findings suggest that a minimum caloric intake is necessary to prevent depression of hypoxic respiratory drive.

    Conclusions:

    • Parenteral amino acid administration, even sufficient for nitrogen balance, is inadequate to prevent depression of respiratory control mechanisms during starvation.
    • A minimum daily caloric intake is essential for preserving hypoxic ventilatory drive.
    • Hypercapnic ventilatory drive appears to be preserved even with severe caloric restriction if nitrogen balance is maintained.