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Related Experiment Videos

Angina pectoris and cold.

J K Stanghelle, S Nilsson

    International Rehabilitation Medicine
    |January 1, 1983
    PubMed
    Summary

    Cold weather significantly reduces exercise capacity and anginal pain threshold in patients with angina pectoris. Nitroglycerin improved cold-induced exercise tolerance by lowering blood pressure.

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    Area of Science:

    • Cardiology
    • Environmental Medicine
    • Exercise Physiology

    Background:

    • Angina pectoris is a condition characterized by chest pain due to reduced blood flow to the heart.
    • Patients with angina may experience heightened symptoms in cold environments.
    • Cold intolerance is a reported symptom in some individuals with cardiovascular conditions.

    Purpose of the Study:

    • To investigate the impact of cold temperatures on exercise capacity and anginal pain threshold in patients with angina pectoris.
    • To evaluate the efficacy of nitroglycerin in mitigating cold-induced reductions in exercise performance.

    Main Methods:

    • Ten patients diagnosed with angina pectoris and cold intolerance underwent symptom-limited exercise tests.
    • Tests were conducted at two different ambient temperatures: +18 degrees C (room temperature) and -17 degrees C (cold).
    • Work capacity and the workload eliciting anginal pain were recorded. Nitroglycerin was administered in a subset of tests.

    Main Results:

    • Exercise capacity was 20% lower at -17 degrees C compared to +18 degrees C.
    • Nine out of ten patients experienced anginal pain at a lower workload in the cold.
    • Nitroglycerin administration prior to cycling in the cold increased work capacity to levels comparable to room temperature conditions, primarily by reducing systolic blood pressure.

    Conclusions:

    • Cold environmental temperatures significantly impair exercise capacity and lower the anginal pain threshold in patients with angina pectoris.
    • Nitroglycerin demonstrates effectiveness in improving exercise tolerance in cold conditions for these patients, likely through its vasodilatory effects on blood pressure.

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