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Nitroglycerin therapy in acute myocardial infarction--an overview
Zeitschrift Fur Kardiologie
|January 1, 1983
Summary
Nitroglycerin may benefit patients with acute myocardial infarction, particularly those with left ventricular failure. Studies show it reduces myocardial ischemia, necrosis, and ventricular arrhythmias, with promising prognostic data.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Nitroglycerin and nitrates are traditionally contraindicated in acute myocardial infarction.
- However, beneficial effects have been observed in patients with left ventricular failure.
Purpose of the Study:
- To review available literature on nitroglycerin's influence in acute myocardial infarction.
- To assess its effects on myocardial ischemia, infarct size, necrosis, ventricular arrhythmias, and prognosis.
Main Methods:
- Literature review of studies investigating nitroglycerin in acute myocardial infarction.
Main Results:
- Consistent beneficial effects of nitroglycerin on myocardial ischemia and QRS signs of necrosis.
- Evidence of reduced creatine kinase (CK and CKMB) activity in some studies.
- Effective reduction in ischemia-related ventricular dysrhythmias.
- Promising data regarding patient prognosis.
Conclusions:
- Nitroglycerin demonstrates beneficial effects in managing acute myocardial infarction, especially with left ventricular failure.
- It effectively reduces ischemia, necrosis, and arrhythmias, suggesting a positive impact on prognosis.