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Related Experiment Videos

Mycoplasmas and arthritis.

E Jansson, A Backman, K Hakkarainen

    Zeitschrift Fur Rheumatologie
    |November 1, 1983
    PubMed
    Summary

    Mycoplasma species cause animal arthritis, with some mimicking human rheumatoid arthritis. Renewed research with new methods may clarify mycoplasma

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    Area of Science:

    • Veterinary Medicine
    • Human Rheumatology
    • Microbiology

    Background:

    • At least 13 mycoplasma species are known to cause arthritis in animals.
    • Mycoplasma hyorhinis (swine) and Mycoplasma synoviae (poultry) infections exhibit clinical and histological similarities to human rheumatoid arthritis.
    • A small percentage (0.9%) of human Mycoplasma pneumoniae infections result in arthritis, which can be mild or a dominant clinical feature.

    Purpose of the Study:

    • To investigate the potential role of mycoplasmas in human joint diseases.
    • To encourage renewed research efforts using advanced methodologies to study fastidious mycoplasmas in human arthritis.

    Main Methods:

    • Review of existing literature on mycoplasma-induced arthritis in animals and humans.
    • Mention of past difficulties in isolating and subculturing fastidious mycoplasmas from human joint fluid.
    • Highlighting the availability of new methods for potential future research.

    Main Results:

    • Mycoplasma pneumoniae and Ureaplasma urealyticum have been previously cultured from human synovial fluid.
    • Isolation of fastidious mycoplasmas from human joint fluid has been challenging for researchers.
    • Existing evidence suggests a possible link between mycoplasma infections and human arthritis.

    Conclusions:

    • Mycoplasma infections are a significant cause of arthritis in various animal species.
    • The clinical presentation of some animal mycoplasmal arthritis models human rheumatoid arthritis.
    • Further investigation utilizing contemporary techniques is warranted to ascertain the role of mycoplasmas in human joint diseases.

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