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Human ultralente insulin.

R R Holman, J Steemson, P Darling

    British Medical Journal (Clinical Research Ed.)
    |March 3, 1984
    PubMed
    Summary
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    Human ultralente insulin effectively controls blood sugar in diabetics, matching beef insulin

    Area of Science:

    • Endocrinology
    • Metabolic Diseases
    • Pharmacology

    Background:

    • Human insulin's solubility and faster action raised concerns about long-acting formulations for basal insulin needs.
    • Doubts existed regarding the efficacy of human insulin in providing sustained basal glycemic control for diabetic patients.

    Purpose of the Study:

    • To evaluate the efficacy of human ultralente insulin compared to beef ultralente insulin in controlling basal plasma glucose concentrations in diabetics.
    • To assess the antigenicity of human insulin versus beef insulin.

    Main Methods:

    • A double-blind, crossover study involving 18 diabetic patients.
    • Comparison of basal plasma glucose concentrations and overnight glucose rise between human and beef ultralente insulin.
    • Measurement of bovine insulin antibody binding.

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    Main Results:

    • Human ultralente insulin demonstrated comparable efficacy to beef ultralente insulin in managing basal plasma glucose levels.
    • No significant difference was observed in overnight plasma glucose rise between human and beef insulin.
    • Human insulin showed significantly reduced bovine insulin antibody binding, indicating lower antigenicity.

    Conclusions:

    • Once-daily human ultralente insulin is a suitable formulation for meeting the basal insulin requirements of diabetic patients.
    • Human insulin is less antigenic than beef insulin, offering a potential advantage in diabetes management.