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Synthesis of no-carrier-added L- and D-[1-11C]-DOPA
The International Journal of Applied Radiation and Isotopes
|December 1, 1983
Abstract:
No-carrier-added DL-[1-11C]-DOPA has been synthesized by carboxylation of an alpha-lithioisocyanide with a radiochemical yield of up to 15% without correction for decay. The total synthesis time is 30 min. The resolution of the D- and L-isomers was accomplished within 16 min by HPLC using a chiral stationary phase and a phosphate buffer of pH 4.5 as eluent.