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Related Experiment Videos

Extralymphatic involvement in diffuse non-Hodgkin's lymphoma.

S Paryani, R T Hoppe, J S Burke

    Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
    |November 1, 1983
    PubMed
    Summary

    This study on non-Hodgkin lymphoma found that bulky disease or multiple extralymphatic sites significantly worsened patient prognosis. Treatment with irradiation or combined modalities yielded similar outcomes, with most relapses occurring distantly.

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    Area of Science:

    • Oncology
    • Hematology
    • Clinical Medicine

    Background:

    • Extralymphatic involvement is common in non-Hodgkin lymphoma (NHL).
    • Understanding prognostic factors and treatment outcomes for extralymphatic NHL is crucial.

    Purpose of the Study:

    • To analyze the outcomes of patients with stage I/II extralymphatic non-Hodgkin lymphoma.
    • To identify prognostic factors influencing survival and relapse in this patient cohort.

    Main Methods:

    • Retrospective analysis of 111 patients with stage IE and IIE extralymphatic NHL treated between 1961-1982.
    • Utilized lymphangiography, bone marrow biopsy, and staging laparotomy for diagnosis and staging.
    • Kaplan-Meier survival analysis and freedom from relapse (FFR) calculations were performed.

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    Main Results:

    • Five-year survival was 46%, and 10-year survival was 36%.
    • Five-year freedom from relapse (FFR) was 49%, with no late relapses observed.
    • Bulky disease (>10 cm) or >3 involved sites significantly reduced survival and FFR.
    • Gastrointestinal tract, head and neck, and lung were common extralymphatic sites; prognosis was site-independent.
    • Most relapses (62%) occurred in distant extralymphatic sites.

    Conclusions:

    • Extralymphatic NHL stage I/II prognosis is negatively impacted by bulky disease and multiple extralymphatic sites.
    • Irradiation and combined modality therapy showed comparable outcomes.
    • Distant extralymphatic relapse is the predominant pattern in this disease subset.