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A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Folic acid and total parenteral nutrition
JPEN. Journal of Parenteral and Enteral Nutrition
|January 1, 1984
Summary
Folic acid is stable in parenteral nutrition solutions above pH 5.0. A daily dose of 1.2 mg is recommended for patients receiving parenteral nutrition to ensure adequate folate levels.
Area of Science:
- Nutritional Science
- Clinical Pharmacy
Background:
- Parenteral nutrition (PN) is crucial for patients unable to consume food orally.
- Folic acid is an essential nutrient often included in PN formulations.
- Ensuring the stability and adequate dosing of folic acid in PN is vital for patient health.
Purpose of the Study:
- To determine the stability of folic acid in parenteral nutrition solutions.
- To assess the efficacy of different folic acid dosages in patients requiring PN.
Main Methods:
- In vitro stability testing of folic acid in various PN solutions over two weeks.
- Clinical assessment of folic acid dosing in a cohort of PN patients.
Main Results:
- Folic acid remained stable in PN solutions when the pH was maintained above 5.0.
- A daily dose of 0.2 mg of folic acid was insufficient for patients on PN.
- A daily dose of 1.2 mg of folic acid for seven days effectively increased serum folate concentrations.
Conclusions:
- Folic acid is stable and deliverable in PN solutions if pH remains above 5.0.
- A daily folic acid dosage of 1.2 mg is recommended for patients receiving parenteral nutrition.
- Adequate folic acid supplementation is essential for patients on long-term parenteral nutrition.
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