Stress, predisposition and the onset of serious disease: implications about psychosomatic etiology

Based on the author's own work and a review of the literature, the hypothesis is made that potentially lethal disease does not usually occur in healthy animals or people but does so when covert or overt disease exists or when a predisposition for disease exists. The author supports this hypothesis in his assessment of the human literature on sudden death. Further support for the hypothesis is presented from 2 animal models being studied in his laboratory--stress-induced heart failure in the cardiomyopathic hamster and stress-induced sensitization of digitalis-toxic ventricular arrhythmias. This analysis suggests a different view from the classical one of what a psychosomatic disease might be.