Clinical observations in ethyl mercury chloride poisoning

Forty-one patients in the Peoples Republic of China were poisoned by ethyl mercury chloride, caused by the ingestion of rice that had been treated with the chemical. A dose-response relationship was found. Five months after the onset of the intoxication, the patients were still in poor condition. They were treated with two chelating agents, sodium dimercaptopropane sulfonate (DMPS) and sodium dimercaptosuccinate (DMS), whose effects were compared. Both agents were effective but DMPS was superior. Although urinary excretion is not the best estimate of body burden in alkyl mercury intoxication, during chelation therapy urinary mercury was an effective indicator for diagnosis and assessment of the degree of intoxication. Chelation therapy was diagnosis and assessment of the degree of intoxication. Chelation therapy was useful as long as the urinary mercury level was elevated.