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Effect of bromocriptine on menstrual cycle length.
British Journal of Obstetrics and Gynaecology
|March 1, 1984
Summary
Bromocriptine treatment significantly shortened the follicular phase in women with regular cycles. This effect, observed across different doses, is attributed to lowered prolactin levels, while the luteal phase remained unaffected.
Area of Science:
- Reproductive endocrinology
- Pharmacology
Background:
- Menstrual cycle regulation involves complex hormonal interactions.
- Elevated prolactin levels can disrupt normal ovulation and cycle length.
Purpose of the Study:
- To investigate the effect of bromocriptine on follicular and luteal phase length in women with normal cycles.
- To determine if bromocriptine dosage influences these changes.
Main Methods:
- Forty-seven women with regular ovulatory cycles and normal prolactin were treated with varying bromocriptine doses.
- Daily plasma gonadotropin concentrations were measured to determine phase lengths.
Main Results:
- Bromocriptine significantly reduced the median follicular phase length from 12.7 to 11.7 days (first cycle) and 10.7 days (second cycle).
- The luteal phase length remained unchanged.
- Follicular phase reduction was independent of bromocriptine dosage.
Conclusions:
- Bromocriptine effectively shortens the follicular phase in women with regular cycles.
- The observed effect is a direct consequence of prolactin level reduction.