[Control of medication in chemotherapy. Examination of the urine for antibacterial activity]

The actual intake of antibiotics was tested in patients who were or were not known to be on antibiotic prescriptions. Using the B. subtilis (ATCC 6051) inhibitory test, the presence of antibiotics in the urine can be demonstrated specifically and at low concentrations. Of 2700 patients not known to be taking antibiotics, 8% had antibiotics in their urine. Of 400 patients with written prescriptions for antibiotics 25% had no antibiotic activity in urine. In order to avoid treatment failures, regular control of medications with the B. subtilis inhibitory test should be undertaken, especially in patients receiving oral chemotherapy.