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Lectins in diagnostic microbiology.

R Doyle, K Keller

    European Journal of Clinical Microbiology
    |February 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Lectins are increasingly valuable for identifying infectious agents like bacteria and fungi through agglutination reactions. Their specificity, speed, and cost make them attractive for diagnostic microbiology.

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    Area of Science:

    • Microbiology
    • Immunology
    • Biochemistry

    Background:

    • Current laboratory identification of infectious agents relies on various methods.
    • Lectins, carbohydrate-binding proteins, show potential as diagnostic reagents.

    Purpose of the Study:

    • To review the utility of lectins in the laboratory identification of infectious agents.
    • To highlight the advantages of using lectins as diagnostic reagents.

    Main Methods:

    • Literature review of studies utilizing lectins for microbial identification.
    • Analysis of lectin properties relevant to diagnostic applications (specificity, stability, rapidity, cost).

    Main Results:

    • Lectins can identify bacteria, fungi, and protozoa through binding or agglutination reactions.

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  • Assay kits combining lectin agglutination with enzyme determinations are proposed for bacterial identification.
  • Key factors like specificity, stability, speed, and cost contribute to lectins' attractiveness.

    • Conclusions:

    • Lectins are valuable reagents for the laboratory identification of infectious agents.
    • The use of lectins in diagnostic microbiology is expected to increase due to their favorable characteristics.