[Problems with the addition of sulfite to infusion solutions]

Sulfites are added to certain infusion solutions in order to prevent non-enzymic browning and decomposition during sterilization. Sulfites are extremely reactive, pharmacologically active compounds. Some undesired reactions are proven, others are suspected. Of special relevance with regard to the application of sulfite-containing infusion solutions is the destruction of thiamine, a possibly hepatotoxic effect of tryptophan-conversion products, and reports on severe asthmatic reactions. Therefore, declaration of sulfite addition to infusion solutions (calculated as SO2) and a warning notice is recommended.