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Ceftazidime and renal function.

K Alestig, B Trollfors, R Andersson

    The Journal of Antimicrobial Chemotherapy
    |February 1, 1984
    PubMed
    Summary
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    Ceftazidime therapy may reduce kidney function in patients with impaired renal function, indicated by decreased glomerular filtration rate (GFR) and increased urinary alanine aminopeptidase. Caution is advised when prescribing ceftazidime to patients with pre-existing kidney issues.

    Area of Science:

    • Nephrology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Glomerular filtration rate (GFR) is a key indicator of kidney function.
    • Antibiotics like ceftazidime can potentially impact renal function.
    • Patients with impaired renal function require careful drug management.

    Purpose of the Study:

    • To evaluate the effect of ceftazidime on kidney function in patients.
    • To assess changes in GFR and renal biomarkers during ceftazidime therapy.
    • To determine the safety of ceftazidime in patients with pre-existing renal impairment.

    Main Methods:

    • 16 patients with initial GFR between 30-110 ml/min received ceftazidime 2g bid.
    • GFR was measured using 51Chrome-EDTA clearance.
    • Urinary alanine aminopeptidase excretion and serum creatinine levels were monitored.

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    Main Results:

    • A mean decrease of 10 ml/min in GFR was observed during ceftazidime therapy.
    • Increased urinary alanine aminopeptidase excretion was noted.
    • Three patients with lower initial GFR (17-22 ml/min) showed increased serum creatinine.

    Conclusions:

    • Ceftazidime may negatively impact kidney function, particularly in patients with impaired renal function.
    • The drug can cause a reduction in GFR and elevated renal biomarkers.
    • Caution is recommended when using ceftazidime in patients with renal impairment, and co-administration with nephrotoxic drugs should be studied.