Dithiocarbamate pesticides: activity of Propineb in the micronucleus test in mice

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A Rolandi, E De Marinis, M De Caterina

    Mutation Research
    |March 1, 1984
    PubMed

    Insights

    Propineb and its metabolite propylene-thiourea (PLTU) showed no clastogenic activity in a mouse micronucleus test. These findings suggest Propineb is not genotoxic, as indicated by the absence of induced micronuclei.

    Area of Science:

    • Toxicology
    • Genetics
    • Environmental Science

    Background:

    • Propineb is a fungicide used in agriculture.
    • Concerns exist regarding the potential genotoxicity of pesticides and their metabolites.
    • Propylene-thiourea (PLTU) is a primary metabolite of Propineb.

    Purpose of the Study:

    • To evaluate the clastogenic potential of Propineb and its metabolite, PLTU.
    • To determine if Propineb or PLTU can induce chromosomal damage.

    Main Methods:

    • The in vivo micronucleus test in mice (Schmid protocol) was employed.
    • Different doses of Propineb, technical grade Propineb, and PLTU were administered.
    • Methyl methanesulfonate (MMS) and mitomycin C (MMC) were used as positive controls.

    Main Results:

    • No statistically significant increase in micronucleated cells was observed for Propineb, technical Propineb, or PLTU at any tested dose.
    • Dose-effect curves for positive controls MMS and MMC confirmed the validity of the test system.

    Conclusions:

    • Propineb and its main metabolite PLTU do not exhibit clastogenic activity in vivo.
    • The results indicate a lack of genotoxic potential for Propineb under the conditions tested.

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