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Updated: Aug 11, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
[Problems in the pathogenesis of respiratory disorders occurring under +Gz loads in combination with breathing of
Abstract:
The effect of accelerations of different value and duration combined with air or pure oxygen breathing on the pulmonary function was investigated in centrifugation experiments on six healthy male test subjects, aged 20--23. The dynamics of the emergence and back development of the respiratory syndrome induced by the combined effect of acceleration and pure oxygen breathing, its symptoms, spyrographic and roentgenologic components were studied. It was demonstrated that both the value and duration of acceleration played a certain role in the pathogenesis of functional disorders of the respiratory system and atelectasis; however, the time factor exerted the major effect on their development.
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