Central respiratory CO2 sensitivity at extreme hypocapnia

In 7 cats anaesthetized with chloralose-urethane the ponto-medullary region was artificially perfused with blood having PaCO2 values (central PaCO2) in the range of 0.3-4.5 kPa. The ventilatory response to changes in central PaCO2 was measured at constant hypercapnic and hypoxic conditions in the systemic circulation. Ventilation decreased upon lowering the central PaCO2 down to values of 0.5 kPa. There was no threshold for the effect of the central PaCO2 on ventilation. The CO2 sensitivity was undiminished at extreme hypocapnia compared to eucapnia. Under extreme central hypocapnic conditions the breathing pattern became irregular. It is concluded that there is still central CO2 sensitivity related to ventilation at extreme hypocapnia. Our findings suggest that central chemosensitive structures have a neural threshold below a PaCO2 of 0.5 kPa.