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Abstract:
Preputial gland abscesses were found in 321 (1.8%) of 17,422 mice from our production colonies. The lesions were observed only in males, and Staphylococcus aureus was isolated in pure culture from 84% of the cases. Experimental transmission of the disease was successfully accomplished through injection of Staphylococcus aureus into the penile urethra.
Insights
Preputial gland abscesses affect 1.8% of male mice in production colonies. Staphylococcus aureus infection, transmitted via the penile urethra, is the primary cause.
Area of Science:
- Veterinary Medicine
- Microbiology
- Animal Health
Background:
- Preputial gland abscesses are a notable health issue in laboratory mouse production colonies.
- These lesions impact animal welfare and research reproducibility.
Purpose of the Study:
- To investigate the incidence, causative agent, and transmission route of preputial gland abscesses in production mice.
- To identify the primary bacterial pathogen responsible for these infections.
Main Methods:
- Retrospective analysis of 17,422 mice from production colonies.
- Bacteriological isolation and identification of pathogens from abscesses.
- Experimental inoculation studies to confirm transmission.
Main Results:
- Preputial gland abscesses were diagnosed in 321 mice (1.8% incidence).
- Lesions occurred exclusively in male mice.
- Staphylococcus aureus was isolated in pure culture from 84% of affected mice.
- Experimental transmission was confirmed via penile urethral injection of S. aureus.
Conclusions:
- Staphylococcus aureus is the predominant causative agent of preputial gland abscesses in male laboratory mice.
- The penile urethra serves as a likely route for S. aureus entry and subsequent abscess formation.
- Implementing targeted hygiene and monitoring protocols may help control S. aureus in mouse production facilities.