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Related Experiment Videos

Perputial gland abscess in mice.

C C Hong, R D Ediger

    Laboratory Animal Science
    |April 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Preputial gland abscesses affect 1.8% of male mice in production colonies. Staphylococcus aureus infection, transmitted via the penile urethra, is the primary cause.

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    Area of Science:

    • Veterinary Medicine
    • Microbiology
    • Animal Health

    Background:

    • Preputial gland abscesses are a notable health issue in laboratory mouse production colonies.
    • These lesions impact animal welfare and research reproducibility.

    Purpose of the Study:

    • To investigate the incidence, causative agent, and transmission route of preputial gland abscesses in production mice.
    • To identify the primary bacterial pathogen responsible for these infections.

    Main Methods:

    • Retrospective analysis of 17,422 mice from production colonies.
    • Bacteriological isolation and identification of pathogens from abscesses.
    • Experimental inoculation studies to confirm transmission.

    Main Results:

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    • Preputial gland abscesses were diagnosed in 321 mice (1.8% incidence).
    • Lesions occurred exclusively in male mice.
    • Staphylococcus aureus was isolated in pure culture from 84% of affected mice.
    • Experimental transmission was confirmed via penile urethral injection of S. aureus.

    Conclusions:

    • Staphylococcus aureus is the predominant causative agent of preputial gland abscesses in male laboratory mice.
    • The penile urethra serves as a likely route for S. aureus entry and subsequent abscess formation.
    • Implementing targeted hygiene and monitoring protocols may help control S. aureus in mouse production facilities.