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Two methods for producing peripheral anosmia in dogs.

K A Houpt, P Shepherd, H F Hintz

    Laboratory Animal Science
    |April 1, 1978
    PubMed
    Summary
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    Researchers developed two methods to induce temporary loss of smell in dogs. One used zinc sulfate for long-term anosmia, while a tracheostomy tube provided short, reversible olfactory disruption.

    Area of Science:

    • Veterinary Science
    • Neuroscience
    • Olfactory Research

    Background:

    • Peripheral anosmia, or loss of smell, is a significant condition in veterinary medicine.
    • Understanding olfactory pathways is crucial for diagnosing and treating smell-related disorders.
    • Developing reliable methods to induce and study anosmia in animal models is essential for research.

    Purpose of the Study:

    • To describe and evaluate two distinct methods for inducing peripheral anosmia in canine subjects.
    • To compare the efficacy, duration, and reversibility of each method.
    • To discuss the practical advantages and limitations of both techniques for future research applications.

    Main Methods:

    • Peripheral anosmia was induced via intranasal infusion of 3.5% zinc sulfate solution.

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  • A second method involved inserting a tracheostomy tube with an inflatable cuff to block airflow to the olfactory mucosa.
  • Olfactory function was assessed to determine the onset, duration, and recovery of anosmia.

    • Main Results:

    • Intranasal zinc sulfate produced anosmia lasting at least six weeks, often for several months.
    • Tracheostomy tube insertion with cuff inflation resulted in reversible anosmia for short periods.
    • Deflation of the tracheostomy tube cuff successfully restored functional olfaction.

    Conclusions:

    • Both zinc sulfate infusion and tracheostomy tube insertion are effective in producing peripheral anosmia in dogs.
    • Zinc sulfate offers a longer-lasting effect, suitable for studies requiring sustained olfactory deficit.
    • The tracheostomy method provides a transient and reversible anosmia, valuable for short-term experimental manipulations.