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The combined effects of pregnancy and repeated plasma exchange on serum cholinesterase activity
Fourteen patients are described in whom repeated plasma exchange was performed as part of their treatment for Rh alloimmunisation during pregnancy. Despite administration of fresh frozen plasma at frequent intervals during therapy, serum cholinesterase activity was shown to be reduced to levels sufficient to put many of them at risk from suxamethonium sensitivity. It is recommended that if short-acting muscle relaxants are intended to be used during the delivery of such patients, a careful investigation of cholinesterase status should be undertaken beforehand.
Fourteen patients are described in whom repeated plasma exchange was performed as part of their treatment for Rh alloimmunisation during pregnancy. Despite administration of fresh frozen plasma at frequent intervals during therapy, serum cholinesterase activity was shown to be reduced to levels sufficient to put many of them at risk from suxamethonium sensitivity. It is recommended that if short-acting muscle relaxants are intended to be used during the delivery of such patients, a careful investigation of cholinesterase status should be undertaken beforehand.