Related Experiment Videos
Molecular analysis of the anti-GAT repertoire in three strains of mice
GAT-specific antibodies which express the CGAT (or pGAT) public idiotypic specificities are encoded by a paucigene system. Antibodies expressing discrete specificities, i.e. anti-GAT and anti-NP, appeared to use the same VH germ-line genes, an observation which directly supports the importance of random H-L pairing to generate a large number of distinct antibody molecules.
GAT-specific antibodies which express the CGAT (or pGAT) public idiotypic specificities are encoded by a paucigene system. Antibodies expressing discrete specificities, i.e. anti-GAT and anti-NP, appeared to use the same VH germ-line genes, an observation which directly supports the importance of random H-L pairing to generate a large number of distinct antibody molecules.