Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intestinal permeability in the newborn.

L T Weaver, M F Laker, R Nelson

    Archives of Disease in Childhood
    |March 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Newborn gut permeability decreases with maturity. Preterm infants show higher intestinal permeability to lactulose, which improves with early oral feeds, suggesting gut immaturity rather than adaptive processes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Intrafamilial Genotyping of Helicobacter pylori from Faecal DNA.

    Gastroenterology research and practice·2011
    Same author

    How did babies grow 100 years ago?

    European journal of clinical nutrition·2010
    Same author

    Systematic review: medical and nutritional interventions for the management of intestinal failure and its resultant complications in children.

    Alimentary pharmacology & therapeutics·2010
    Same author

    McCance and Widdowson - A Scientific Partnership of 60 Years.

    Archives of disease in childhood·2010
    Same author

    Drug misuse in pregnancy: losing sight of the baby?

    Archives of disease in childhood·2009
    Same author

    Transenteric signalling: mammary messages or white noise?

    Advances in experimental medicine and biology·2009
    Same journal

    Diagnostic accuracy study assessing the ability of paediatric asthma scores to predict admission following initial emergency department bronchodilator therapy: a Clinical Asthma Scoring systems in Paediatric Emergency (CASPER) study.

    Archives of disease in childhood·2026
    Same journal

    Artificial intelligence for child health: current capabilities and the next frontier.

    Archives of disease in childhood·2026
    Same journal

    Troubled origins and lasting impact of the first insulin injection.

    Archives of disease in childhood·2026
    Same journal

    Paediatric readiness assessment tools in emergency care: a scoping review.

    Archives of disease in childhood·2026
    Same journal

    Building a paediatric workforce to deliver the NHS prevention agenda: time for paediatric public health medicine?

    Archives of disease in childhood·2026
    Same journal

    Impact of antenatal biological response modifying drugs on infant infection risk and vaccination rates: a national cohort study.

    Archives of disease in childhood·2026
    See all related articles

    Area of Science:

    • Neonatal physiology
    • Gastrointestinal research
    • Pediatric nutrition

    Background:

    • Assessing passive intestinal permeability is crucial for understanding neonatal gut function.
    • Lactulose and mannitol are established markers for evaluating paracellular and transcellular pathways, respectively.
    • Urinary recovery of these markers serves as a reliable indicator of intestinal uptake.

    Purpose of the Study:

    • To investigate passive intestinal permeability in newborn infants using lactulose and mannitol.
    • To compare gut permeability in preterm versus mature newborns.
    • To observe changes in intestinal permeability during the initial week of oral feeding.

    Main Methods:

    • Administered feeds containing lactulose and mannitol to 33 newborn babies.

    Related Experiment Videos

  • Measured urinary recovery of lactulose and mannitol as indicators of intestinal uptake.
  • Correlated permeability markers with gestational age and postnatal feeding duration.

    • Main Results:

    • Infants born before 34 weeks' gestation demonstrated significantly higher lactulose permeability compared to more mature infants.
    • All preterm infants exhibited a notable decrease in lactulose absorption within the first week of oral feeds.
    • Newborns between 34 and 37 weeks' gestation reached mature lactulose permeability within four days of commencing oral feeds.

    Conclusions:

    • Preterm infants possess immature intestinal permeability, indicated by higher lactulose passage.
    • Early oral feeding appears to facilitate a decline in intestinal permeability in preterm infants.
    • The observed permeability changes likely reflect gut immaturity rather than a specific adaptation to enteral nutrition.