Related Experiment Video
Updated: Aug 8, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Retrohydroxamate ferrichrome, a biomimetic analogue of ferrichrome
Abstract:
A new synthetic analogue of ferrichrome, retrohydroxamate ferrichrome, has been examined for biological activity. Although spectroscopic evidence indicates that the analogue is a weaker Fe(III) chelator than ferrichrome, retrohydroxamate ferrichrome is indistinguishable from ferrichrome in its growth factor activity for Arthrobacter flavescens, and in its potency in antagonizing the antibiotic activity of albomyhcin against Bacillus subtilis. It is as active as ferrichrome as a siderophore for the fungus, Ustaligo sphaerogena. In contrast, desmethylretrohydroxamate ferrichrome shows no significant biological activity.
Related Concept Videos
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
Indirect-Acting Cholinergic Agonists: Mechanism of Action
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex, leading to...
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
Microbes and Other Elemental Cycles

