Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid function in patients with homozygous beta-thalassaemia.

C Phenekos, A Karamerou, P Pipis

    Clinical Endocrinology
    |April 1, 1984
    PubMed
    Summary

    Patients with beta-thalassaemia on iron chelation therapy showed signs of compensated hypothyroidism, indicated by low thyroxine levels and an exaggerated TSH response to TRH stimulation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hormonal activity of adrenal incidentalomas: results from a long-term follow-up study.

    Clinical endocrinology·2008
    Same author

    Effect of metformin plus roziglitazone compared with metformin alone on glycaemic control in well-controlled Type 2 diabetes.

    Diabetic medicine : a journal of the British Diabetic Association·2006
    Same author

    Diffuse idiopathic colonic varices presenting with lower gastrointestinal bleeding in an elderly patient: a case report and review of the literature.

    Acta gastro-enterologica Belgica·2006
    Same author

    Development and validation of a simple reversed-phase high-performance liquid chromatography method for the determination of testosterone in serum of males.

    Journal of pharmaceutical and biomedical analysis·2006
    Same author

    Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study.

    The Journal of clinical endocrinology and metabolism·2005
    Same author

    Influence of fetal body weight on metabolic complications in adult life: review of the evidence.

    Journal of pediatric endocrinology & metabolism : JPEM·2002

    Area of Science:

    • Endocrinology
    • Hematology
    • Pediatric Endocrinology

    Background:

    • Homozygous beta-thalassaemia requires frequent blood transfusions.
    • Transfusional iron overload is a common complication managed with Desferrioxamine.
    • Endocrine dysfunction, including thyroid abnormalities, can occur in thalassaemia patients.

    Purpose of the Study:

    • To evaluate thyroid function in young patients with homozygous beta-thalassaemia.
    • To assess the impact of chronic blood transfusions and iron chelation on thyroid hormones.
    • To investigate the presence of compensated hypothyroidism in this patient group.

    Main Methods:

    • Assessed thyroid function tests: total thyroxine (T4), T3-uptake, total triiodothyronine (T3), and reverse triiodothyronine (rT3).

    Related Experiment Videos

  • Administered a standard thyrotropin-releasing hormone (TRH) stimulation test.
  • Checked for thyroid antibodies and calculated the free thyroxine index (FTI).

    • Main Results:

    • Significantly lower total T4 and FTI observed in patients compared to controls.
    • Total T3 and rT3 levels were comparable between patients and controls.
    • Patients exhibited a significantly higher TSH increase post-TRH stimulation, despite normal basal TSH.

    Conclusions:

    • Patients with homozygous beta-thalassaemia on chronic transfusion and Desferrioxamine therapy may develop compensated hypothyroidism.
    • Low total T4 and FTI, coupled with an exaggerated TSH response to TRH, suggest subclinical thyroid dysfunction.
    • Regular thyroid function monitoring is recommended for patients with beta-thalassaemia.