Noxythiolin--high-performance liquid chromatographic assay and stability

A rapid stability-indicating high-performance liquid chromatographic assay for noxythiolin has been developed and its application to the determination of the shelf-life of solid and solution forms is illustrated. Kinetic models which describe the degradation profile have been evaluated and concentrated solutions are modelled by a A B + C system whereas more dilute solutions approximate to the A B or limiting first-order case.