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Enteric-coated aspirin, platelet cyclooxygenase activity and function.

G H Rao, E Radh, G J Johnson

Prostaglandins, Leukotrienes, and Medicine

|March 1, 1984

Summary

Slow-release enteric-coated aspirin effectively inhibits platelet function, similar to regular aspirin. However, its slow-releasing nature delays the onset of action, impacting cyclooxygenase activity.

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Area of Science:

Pharmacology
Biochemistry
Cardiovascular Research

Background:

Contradictory findings exist on the bioavailability and duration of action for slow-releasing enteric-coated aspirin formulations.
Platelet function and arachidonic acid metabolism are key targets for aspirin's therapeutic effects.

Purpose of the Study:

To evaluate the effects of a single dose of two commercial enteric-coated aspirin formulations on platelet function and arachidonic acid metabolism.
To compare the efficacy and onset of action of slow-releasing aspirin with fast-acting aspirin.

Main Methods:

Human and canine platelet aggregation assays were performed.
Platelet cyclooxygenase activity was measured.
Arachidonic acid metabolism in platelets was analyzed following administration of enteric-coated aspirin.

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Main Results:

A single dose of slow-releasing enteric-coated aspirin demonstrated comparable efficacy to fast-acting aspirin in inhibiting platelet cyclooxygenase activity and function.
The onset of platelet inhibition was significantly delayed with enteric-coated aspirin due to its slow-releasing properties.

Conclusions:

Enteric-coated aspirin formulations are effective in inhibiting platelet function, comparable to regular aspirin.
The delayed onset of action for enteric-coated aspirin should be considered in clinical applications requiring rapid platelet inhibition.