Related Experiment Video

Updated: Aug 15, 2026

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
12:55

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies

Published on: November 27, 2013

Comparison of the kinetics of parenteral and oral gold

N L Gottlieb

    Scandinavian Journal of Rheumatology. Supplement
    |January 1, 1983
    PubMed

    More Related Videos

    A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening08:34

    A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening

    Published on: October 16, 2015

    Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles06:06

    Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles

    Published on: March 9, 2019

    Related Concept Videos

    Routes of Drug Administration: Parenteral01:25

    Routes of Drug Administration: Parenteral

    The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
    The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
    The IV route is often...
    Bioavailability: Overview01:13

    Bioavailability: Overview

    Bioavailability refers to the proportion of an unaltered drug that, after administration, enters the systemic circulation and can be distributed to the desired action site. Factors such as gastrointestinal (GI) absorption and liver biotransformation influence the bioavailability of a drug when it is administered orally. When a drug is administered intravenously, it enters the systemic circulation directly; by definition, its bioavailability is assumed to be 100%. The bioavailability of an...
    Factors Influencing Drug Absorption: Presystemic Elimination01:24

    Factors Influencing Drug Absorption: Presystemic Elimination

    The pharmacokinetic journey of oral drugs begins with a crucial first pass through the hepatic portal system, called the first-pass effect. This first pass significantly impacts bioavailability — the proportion of a drug that enters systemic circulation and is available for therapeutic action. The primary route sees the drug absorbed by intestinal membranes and then shunted to the liver via the hepatic portal vein. Here, pre-systemic elimination occurs as drugs face metabolism or biliary...
    One-Compartment Open Model for IV Bolus Administration: General Considerations01:19

    One-Compartment Open Model for IV Bolus Administration: General Considerations

    The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
    The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant, half-life,...
    Bioavailability: Overview01:17

    Bioavailability: Overview

    Bioavailability refers to the proportion of an administered drug that reaches the systemic circulation in its active, unaltered form. It is a crucial pharmacokinetic parameter that determines the effectiveness of a drug in achieving its intended therapeutic outcomes. The route of administration significantly influences bioavailability, with intravenous administration achieving 100% bioavailability as the drug directly enters the bloodstream. In contrast, oral administration often results in...
    IV Infusion to Oral Dosing: Conversion Methods01:28

    IV Infusion to Oral Dosing: Conversion Methods

    The development of extended-release formulations has facilitated the transition from intravenous to oral medication, offering a more convenient and patient-friendly approach to drug administration. This transition, however, requires careful management to ensure that therapeutic drug levels are maintained, preserving efficacy and avoiding adverse effects. Understanding pharmacokinetic principles and dosage calculations is critical during this process.Pharmacokinetics of the...