[Prevention of urinary calculi with thiazides and allopurinol. A long-term study]

In 30 cases of recurring urinary calcium oxalate and calcium phosphate calculi, renal or absorptive hypercalciuria or hyperuricemia, long term controls of serum and urine electrolytes were made under hydrochlorothiazide and allopurinol therapy. By differentiating the type of hypercalciuria it could be determined, if thiazide-therapy is indicated in renal hypercalciuria only or in the absorptive cases as well. Statistic comparison of the patients with - and without increased urinary sodium excretion solved the question whether high sodium excretion diminishes or abolishes the hypocalciuric thiazide effect. The frequency of stones before and after treatment supports the efficacy of thiazide prophylaxis.