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Related Experiment Videos

Ellipsoids in the human spleen.

N Buyssens, G Paulus, N Bourgeois

    Virchows Archiv. A, Pathological Anatomy and Histopathology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    The human spleen contains millions of ellipsoids (EL), which are specialized capillaries. These structures facilitate lymphocyte transport, acting as the spleen's version of lymph node high endothelial venules.

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    Area of Science:

    • Immunology
    • Histology
    • Vascular Biology

    Background:

    • The spleen plays a crucial role in immune surveillance and fluid filtration.
    • Understanding the microvasculature of the spleen is essential for elucidating immune cell trafficking.

    Purpose of the Study:

    • To investigate the number, structure, and cellular composition of splenic ellipsoids (EL).
    • To determine the role of EL in lymphocyte traffic within the human spleen.

    Main Methods:

    • Analysis of 25 surgically resected human spleen specimens.
    • Histological examination to assess EL number, structure, and surrounding cuff cells.
    • Evaluation of lymphocyte presence within EL walls.

    Main Results:

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  • An average spleen (200g) contains approximately 1.6 x 10^7 EL.
  • EL are capillaries located at the junction of penicilliary arterioles and capillaries.
  • Cuff cells surrounding EL are specialized, dynamic pericapillary cells with lysosomal activity.

    • Conclusions:

    • Splenic ellipsoids (EL) are dynamic histological structures crucial for lymphocyte transit.
    • EL function as the splenic equivalent of lymph node high endothelial venules, facilitating lymphocyte circulation.