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Is ischemia-induced pH decrease of dog myocardium respiratory or metabolic acidosis?

K Ichihara, N Haga, Y Abiko

    The American Journal of Physiology
    |May 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

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    Myocardial ischemia causes acidosis. This study reveals that the resulting acidosis is metabolic, not respiratory, driven by hydrogen ion accumulation rather than carbon dioxide buildup.

    Area of Science:

    • Cardiovascular Physiology
    • Biochemistry

    Background:

    • Ischemia leads to myocardial acidosis and elevated carbon dioxide tension (PCO2).
    • The precise cause of this acidosis (metabolic vs. respiratory) remains debated.

    Purpose of the Study:

    • To investigate whether hydrogen ion accumulation is the cause or result of carbon dioxide accumulation during myocardial ischemia.
    • To differentiate between metabolic and respiratory acidosis in ischemic heart tissue.

    Main Methods:

    • Simultaneous measurement of myocardial pH and PCO2 in canine hearts.
    • Calculation of bicarbonate concentration ([HCO-3]) using the Henderson-Hasselbalch equation.
    • Induction of ischemia via occlusion of the left anterior descending coronary artery (LAD).

    Main Results:

    Related Experiment Videos

    • LAD occlusion resulted in decreased myocardial pH and a significant decrease in [HCO-3], indicating metabolic acidosis.
    • In vitro experiments showed lactic acid decreased pH and [HCO-3] (metabolic), while CO2 increased [HCO-3] and decreased pH (respiratory).
    • The observed decrease in [HCO-3] during ischemia exceeded lactate accumulation, suggesting other factors contribute to metabolic acidosis.

    Conclusions:

    • Ischemic acidosis in the myocardium is primarily metabolic, not respiratory.
    • Hydrogen ion accumulation, rather than CO2 accumulation, is the main driver of acidosis during ischemia.
    • Lactate accumulation alone does not fully explain the extent of metabolic acidosis observed during myocardial ischemia.