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Related Experiment Videos

Airway receptor activity in the developing opossum.

J P Farber, J T Fisher, G Sant'Ambrogio

    The American Journal of Physiology
    |May 1, 1984
    PubMed
    Summary
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    Airway receptor function in opossums matures with age, with slowly adapting receptors (SARs) showing age-dependent changes in discharge rates and dynamic responses. Early lung utilization may drive this functional maturation.

    Area of Science:

    • Physiology
    • Developmental Biology
    • Respiratory System

    Background:

    • Airway receptors play a crucial role in respiratory control.
    • Understanding the developmental trajectory of these receptors is vital for insights into respiratory health.
    • Opossums offer a unique model for studying mammalian development.

    Purpose of the Study:

    • To investigate the developmental characteristics of airway receptor discharge in opossums.
    • To compare the functional maturation of rapidly adapting receptors (RARs) and slowly adapting receptors (SARs) across different age groups.
    • To explore the influence of age and lung utilization on airway receptor function.

    Main Methods:

    • Vagal nerve single-unit recordings were performed in anesthetized, ventilated opossums at 20, 30, 55, and 90 days of age.

    Related Experiment Videos

  • Static and dynamic firing properties of SARs were assessed under varying transpulmonary pressures (Ptp).
  • Responses to CO2 were evaluated in SARs.

    • Main Results:

    • RARs constituted a smaller proportion of sampled receptors in younger opossums (20-30 days).
    • SAR discharge rates increased with age at higher Ptp, similar to placental mammals.
    • Reduced SAR dynamic response in young opossums was proportional to lower firing rates; CO2 inhibition remained consistent across ages.

    Conclusions:

    • Airway receptor function, particularly SARs, undergoes significant maturation with age in opossums.
    • The functional development of SARs in opossums at 50 days resembles adult placental mammals, even at low Ptp.
    • Early lung utilization appears to be a key factor in the functional maturation of airway receptors.