In vitro antibacterial activity of cefpiramide

A microbroth dilution method was used to measure the MICs of cefpiramide (SM 1652), cefotaxime, moxalactam, ceftazidime, cefoperazone, ceftriaxone, piperacillin, and mezlocillin against 921 isolates of gram-negative (701) and gram-positive (220) bacteria. The activity of cefpiramide was equivalent to those of piperacillin and mezlocillin against members of the family Enterobacteriaceae and gram-positive isolates, including enterococci. Cefpiramide had equivalent or slightly greater activity against Pseudomonas aeruginosa than the other beta-lactam antibiotics tested.