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Study on in vivo decarboxylation of D-penicillamine in rats
Arzneimittel-Forschung
|January 1, 1984
Abstract:
Carboxy-labeled 14C-D-penicillamine was prepared and dosed at 50 mg/kg to Sprague-Dawley rats kept in metabolism cages. The recovery of 14C in excreta, tissue and expired air was 98.4%. The 14CO2 expired amounted only to 1.5% of the 14C-dose indicating that in vivo decarboxylation of the drug in rats is not a significant metabolic pathway.