[Effect of CO2 on thrombocyte aggregation in the cat]

The antiaggregation ability of CO2 during ADP- and collagen-induced platelet aggregation has been discovered in cats under hypercapnia. The effect persisted after Pco2 normalization. The inhibition of cyclooxygenase by indomethacin suppressed the antiaggregation activity of CO2 in vivo but not in vitro. While estimating the regulatory role of CO2 in the metabolic control of cerebral circulation, it is also of importance to take into account the antiaggregation ability of CO2.