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Detrusor and urethral dysfunction in prostatic hypertrophy.

J T Andersen, E W Bradley

    British Journal of Urology
    |December 1, 1976
    PubMed
    Summary
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    Transurethral resection of the prostate (TURP) can alter bladder function, often improving detrusor hyperreflexia. TURP also increases maximum urinary flow by shortening urethral length, impacting bladder and urethral function post-surgery.

    Area of Science:

    • Urology
    • Nephrology
    • Physiology

    Background:

    • Prostatic hypertrophy frequently causes lower urinary tract symptoms.
    • Neurogenic bladder dysfunction, including detrusor hyperreflexia, can be associated with prostatic hypertrophy.
    • Transurethral resection of the prostate (TURP) is a common surgical intervention.

    Purpose of the Study:

    • To assess the impact of TURP on bladder and urethral function.
    • To investigate changes in detrusor reflex activity and urethral function post-TURP.
    • To correlate surgical outcomes with preoperative findings.

    Main Methods:

    • Utilized gas cystometry, detrusor reflex activating procedures, electromyography, and uroflowmetry.
    • Performed urethral pressure profilometry before and after surgery.

    Related Experiment Videos

  • Assessed 9 patients with prostatic hypertrophy undergoing TURP.

    • Main Results:

    • Preoperatively, a high incidence of detrusor hyperreflexia was observed, suggesting neurogenic bladder dysfunction.
    • Post-TURP, a change in detrusor reflex function was noted in some patients.
    • Maximum urinary flow increased significantly due to a shortened functional urethral length; no change in maximum urethral intramural pressure was observed.

    Conclusions:

    • Decompression or injury of prostatic urethral sensory nerve endings appears to influence detrusor function after prostate surgery.
    • TURP effectively improves urinary flow by altering urethral characteristics.
    • The study confirms that TURP impacts both bladder and urethral function, with potential neurogenic implications.