Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

J chain-positive cells in bursectomized chicks.

O Moriya, Y Ichikawa

    Immunology Letters
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Congenital absence of the bursa of Fabricius reduced J chain-positive cells in chicken spleens. However, bone marrow may still support the proliferation of these B cells, indicating incomplete bursa dependence.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Induction of hepatitis C virus-specific cytotoxic T lymphocytes in mice by immunization with dendritic cells treated with an anthrax toxin fusion protein.

    Vaccine·2001
    Same author

    [Evaluation of the usefulness of a serodiagnosis kit, the determiner TBGL antibody for tuberculosis: setting reference value].

    Kekkaku : [Tuberculosis]·1999
    Same author

    Roles of macrophages in programmed cell death and remodeling of tail and body muscle of Xenopus laevis during metamorphosis.

    Histochemistry and cell biology·1998
    Same author

    Spectrin localizations in the chicken bursa of Fabricius at different stages of development.

    Acta histochemica·1996
    Same author

    Ultrastructural localizations of J chains in the chicken bursa of Fabricius at different stages of development.

    Acta histochemica·1995
    Same author

    [Two cases of invasive pulmonary aspergillosis in non-immunocompromised hosts].

    Nihon Kyobu Shikkan Gakkai zasshi·1994

    Area of Science:

    • Immunology
    • Developmental Biology
    • Cell Biology

    Background:

    • The bursa of Fabricius is crucial for B cell development in chickens.
    • J chain is a key component of immunoglobulins, particularly IgM and IgA, produced by B cells.

    Purpose of the Study:

    • To investigate the impact of congenital bursa absence on J chain-positive B cells in chickens.
    • To determine the role of the spleen, thymus, and bone marrow in B cell generation without the bursa.

    Main Methods:

    • Embryonic chickens were treated with testosterone propionate to induce bursa agenesis.
    • J chain-positive cells were quantified in spleen, thymus, and bone marrow at embryonic and post-hatch stages.

    Main Results:

    • A significant reduction in J chain-positive cells was observed in the spleen of chicks lacking the bursa of Fabricius.

    Related Experiment Videos

  • No significant differences in J chain-positive cell numbers were found in the thymus or bone marrow.
  • These findings suggest that while the bursa is important, it's not solely responsible for all J chain-positive B cell generation.

    • Conclusions:

    • Congenital absence of the bursa of Fabricius does not completely abolish the generation of J chain-positive B cells.
    • The bone marrow appears to play a role in the proliferation of some J chain-positive cells in the absence of the bursa.
    • These results highlight the complex and potentially redundant pathways in avian B cell development.