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Updated: Jul 16, 2026
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A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
Published on: May 10, 2013
Comparative study of glomerular filtration rate with diverse labelled agents
International Urology and Nephrology
|January 1, 1984
Summary
This study compared various clearance agents, including 113mIn-EDTA and 99mTc-DTPA, with 3H-inulin in animal models. Results indicate similar homeostatic handling of these agents, despite potential variations in membrane diffusion rates.
Area of Science:
- Pharmacokinetics and Biomedical Imaging
- Renal Physiology and Clearance Studies
Background:
- Accurate measurement of renal clearance is crucial for assessing kidney function.
- Various radiolabeled agents are used to evaluate glomerular filtration rate (GFR).
Purpose of the Study:
- To compare the renal clearance of 113mIn-EDTA, 99mTc-DTPA, and 131I-iothalamate against 3H-inulin.
- To evaluate different clearance measurement methodologies and mathematical modeling.
Main Methods:
- Simultaneous clearance measurements in rabbits and dogs using 113mIn-EDTA, 99mTc-DTPA, 131I-iothalamate, and 3H-inulin.
- Application of classical plateau and single-shot procedures.
- Analysis using a two-compartmental mathematical model.
Main Results:
- All tested agents (113mIn-EDTA, 99mTc-DTPA, 131I-iothalamate, 3H-inulin) exhibited similar homeostatic trends and clearance values.
- Individual membrane diffusion rates may influence agent handling over time.
Conclusions:
- The studied radiolabeled agents serve as comparable indicators for renal clearance.
- Understanding membrane interactions is key to interpreting clearance data variations.
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