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Related Experiment Videos

A vasopressin-induced decrease in pancreatic blood flow and in pancreatic exocrine secretion in the anesthetized dog.

H J Beijer, A H Maas, G A Charbon

    Pflugers Archiv : European Journal of Physiology
    |March 1, 1984
    PubMed
    Summary

    Vasopressin reduces pancreatic blood flow, which in turn decreases pancreatic secretion. This finding clarifies the relationship between blood flow and secretion in the pancreas.

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    Area of Science:

    • Gastroenterology
    • Physiology
    • Endocrinology

    Background:

    • Vasopressin's effects on pancreatic blood flow and secretion are known.
    • The causal relationship between these effects remains unclear.

    Purpose of the Study:

    • To determine if decreased pancreatic blood flow causes decreased pancreatic secretion.
    • To investigate the role of oxygen consumption and extraction.

    Main Methods:

    • Pentobarbital anesthetized dogs infused with secretin to establish steady state.
    • Administration of increasing doses of vasopressin.
    • Measurement of pancreatic blood flow, secretory flow, oxygen consumption, oxygen extraction, and CO2 parameters.

    Main Results:

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  • Vasopressin decreased pancreatic blood flow and secretory flow.
  • A decrease in blood flow preceded the decrease in secretion by approximately 25 seconds.
  • Oxygen extraction increased, while oxygen consumption decreased, suggesting oxygen conservation.

    • Conclusions:

    • Vasopressin-induced decrease in pancreatic blood flow is the primary determinant of decreased pancreatic secretion.
    • Metabolic control of tissue oxygenation plays a role in this phenomenon.